News
Publikation: "Mortality and postinterventional complications after ablative treatment of liver malignancies: A cohort study of 4374 patients"
In der Zeitschrift Official Journal of the American Brachytherapy Society wurde oben genannte Publikation am 23. August 2024 unter Mitwirkung der Co-Autoren Dr. Tim Herrmann und Maximilian Sensse veröffentlicht. Für nähere Informationen siehe diesen Link.
Abstract
PURPOSE: Ablative therapies for primary and secondary liver malignancies are increasingly adopted in current guidelines. Nevertheless, surgical resection remains the gold standard in most curative therapy settings. Extensive studies on mortality and morbidity after ablative treatment of the liver are missing. We investigated complications and mortality after ablative treatment in a large, unselected study cohort.
MATERIALS AND METHODS: Standardized patient and treatment data in 4374 percutaneous and angiographic ablative procedures of the liver from the DRG-based hospital reimbursement system (diagnosis-related groups) of an academic hospital in Germany were retrospectively evaluated. We analyzed descriptive patient data, length of stay (LOS), pre-existing medical conditions, previous gastrointestinal surgeries, severe complications, and occurrence of death.
RESULTS: Treatment of secondary liver malignancies constituted over two-thirds of all procedures (71%, n=3053). The mean LOS was 4.1 ± 3.5 days. Severe complications were documented in 1.4% and in-house death in 0.2% of cases, significantly more often after treatment with chemoembolization of primary liver malignancies (p=0.003; p=0.0001). Previous partial liver resection, partial bowel resection, and chronic renal failure were independent risk factors for the occurrence of severe complications.
CONCLUSION: Severe complications and in-hospital death are rare in the treatment of primary and secondary liver malignancies with percutaneous and angiographic procedures. They are a viable alternative or addition to a surgical approach in treating liver lesions. © 2024 The Authors. Published by Elsevier Inc. on behalf of American Brachytherapy Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Publikation: "Prediction of Severity of Obstructive Sleep Apnea by Awake Impulse Oscillometry"
In der Zeitschrift Sleep Medicine (Science Direct) wurde oben genannte Publikation am 15. Dezember 2024 unter Mitwirkung von Anke Lux veröffentlicht. Für nähere Informationen siehe diesen Link.
Abstract
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Conclusion
Publikation: "More micrometastases, more recurrence? The role of qPCR of PSA mRNA in lymph nodes during prostatectomy"
In der Zeitschrift World Journal of Urology wurde oben genannte Publikation am 5. Januar 2025 unter Mitwirkung von Anke Lux veröffentlicht. Für nähere Informationen siehe diesen Link.
Abstract
Background and objectives
Radical prostatectomy is a standard treatment for prostate cancer, yet about 30% of patients experience rising biochemical markers within a decade post-surgery. Pelvic lymph node sampling during prostatectomy assesses potential lymph node metastases, but standard histological assessments, which typically examine only 2–3 tissue sections, often miss occult metastases. This study assesses the effectiveness of qPCR in detecting PSA coding KLK3 mRNA for identifying lymph node metastases post-prostatectomy and explores the correlation between PSA-mRNA and biochemical recurrence.
Methods
A cohort of 157 patients who underwent radical prostatectomy with lymphadenectomy were examine. On average, 24.7 lymph nodes were removed per patient. Among them, 108 patients reached PSA value below 0.1 ng/ml without receiving additional therapy, and 106 were followed up over a duration of 5.4 years. This subgroup is of particular interest because it allows for the investigation of the correlation between the occurrence of PSA-mRNA in lymph nodes and later biochemical recurrence.
Key findings and limitations
qPCR of PSA-mRNA identified 47 out of 108 positive cases (43.5%), while histopathological examination only detected 16 out of 108 cases (14.8%). From the followed-up subgroup 37 out of 106 patients (34.9%) experienced biochemical recurrence. It is noteworthy that qPCR yields more positive findings, regardless of the presence of biochemical recurrence.
Conclusion and clinical implications
The study findings illustrate that qPCR consistently outperforms conventional histology in detecting lymph node metastases, regardless of biochemical recurrence. The hypothesis that qPCR is better at predicting later biochemical recurrence than conventional histology has not been confirmed.